The stage that they’re at is animal testing but it sounds like it’s been successful in mouse and primate models.
My understanding: The way autoimmune diseases usually seem to work* is the immune system is “flagging” the wrong thing as harmful/not needed and destroying it. The typical treatments for autoimmune diseases are just tamping the entire immune system down so it can’t destroy anything, which leaves a person vulnerable to infection.
The newer method is basically “tricking” the body using a method that… the human body already came up with. Cells flagging the wrong thing apparently happens all the time, so there are multiple defenses against immune disease, and one of them is in the liver. So scientists figured out a way to tell the body “hey, you flagged this wrong” and sent it to the liver and the liver/body recognized this signal.
There is still a lot of work to be done and it sounds like this isn’t foolproof (ie: what if the liver is whats broken? unsure, and what if the immune system flags things wrong again?) but this is literally so amazing. i was tearing up reading it, and i hope that everything goes well in clinical trials.
*theres like a lot medical science doesnt know about the immune system
Thank you for this explanation/synthesis of the article! It’s important for us to understand that they’re still in early development and testing of these methods, but also that they’ve seen it work in mice and primates (rather than just petri dishes of human cells). I hope this goes well.
Hi! I’m a microbiologist and I’ve done work in academia, pharma, and clinical trials.
So the most exciting thing about this article is the last paragraph tbh (working on getting the actual paper, it’s not up on sci-hub yet).
The company mentioned, Anokion, has four registered clinical trials for both Celiac and MS patients. The trial for Celiac just submitted data from their phase 1 trial (meaning there’s good data it is safe) and are recruiting for a Phase ½ trial (meaning they are now testing efficacy). After that, the big hurdle is phase 3, which looks at whether or not it is better than a current treatment. The projected completion date is spring 2025. They are also preparing for a Phase 2 trial but are not yet recruiting.
The phase 1 MS trial is currently active, estimated completion in summer 2024.
I checked the company website and it looks like they are in the process of submitting an investigational new drug (IND) application for Type 1 diabetes. This is the first step to starting clinical safety and efficacy trials.
Now clinical trials can get delayed for a variety of reasons, but this is a really good sign! It’s way further along than I initially thought when seeing the news. If the treatment does well, we could see new drugs on the market for Celiacs as early at 2030ish and MS as early as 2035.
I literally just burst into tears and woke up my partners.
Holy shit. The idea of not having celiac disease anymore is so completely overwhelming.
Update: I have registered for the trial and if you also have celiac and want to register the link is here.
My therapist just told me my problem is that I need to write more fanfiction.
This sounds fake but the logic behind it is actually really interesting? She said obsession with a new fandom triggers quick dopamine release when we consume all this related content–it’s easy and addictive.
What we’re NOT getting is that ‘slow dopamine’ that’s more sustainable and engaging. That’s the kind we get from DOING things that take effort but are ultimately rewarding.
So like, she suggested that writing fic and making fanart are ways to balance the quick dopamine of watching a show/reading fic with the slow dopamine of working at something that takes effort.
Moral of the story is you should engage in the process of creation around your favorite things. You’ll feel better for it.
I wish people would stop saying “It’s July. Well done for wasting half a year.” Did you make someone smile in the past six months? Did you stroke a cat or throw a stick for a dog? Did you learn a new fact or teach someone a new joke? Did you laugh, cry, scream or sing in the past six months? Because if so, congratulations for not wasting your time at all.
I really needed this
I’m bringing this back for December to remind everyone.
You did not waste your year.
If you made it this far, that’s already not wasting your year.
You made it through the year, you laughed, you cried, you smiled, you saw the sun and felt the rain, and most importantly, you’re still here.
A lot of people around me are having kids and every day it becomes more apparent that hitting your children to punish them is insane because literally everything can be a horrible punishment in their eyes if you frame it as such.
Like, one family makes their toddler sit on the stairs for three minutes when he hits his brother or whatever. The stairs are well lit and he can see his family the whole time, he’s just not allowed to get up and leave the stairs or the timer starts over. He fucking hates it just because it’s framed as a punishment.
Another family use a baseball cap. It’s just a plain blue cap with nothing on it. When their toddler needs discipline he gets a timeout on a chair and has to put the cap on. When they’re out and about he just has to wear the cap but it gets the same reaction. Nobody around them can tell he’s being punished because it’s in no way an embarrassing cap, but HE knows and just the threat of having to wear it is enough.
And there isn’t the same contempt afterwards I’ve seen with kids whose parents hit them. One time the kid swung a stick at my dog, his mother immediately made him sit on the stairs, he screamed but stayed put, then he came over to my dog and gently said “Sorry Ellie” and went back to playing like nothing happened, but this time without swinging sticks at the nearby animals.
The psych nerds found out ages ago that punishments that make the child think for a few minutes (about one minute or year of age until they’re tweens) is much more helpful to develope social intelligence and understanding than punishments which prevents thinking, like the ones that involve pain. In fact, corporal punishment encouraged lying, extreme reactions, violent outbursts, go figure, they don’t trust you.
This is all really fucking serious and important and I’m mainly reblogging for that, because this correct mentality needs to be spread around more, but I’m also reblogging because I absolutely lost it at the child who dreads having to wear the normal blue hat of shame.
Gonna be 1000% with you guys. Gonna speak my truth here. People who act like armpits as a sex thing is like this weird crazy thing are the ones who are weird actually. Sexualizing the armpit is intuitive. When you’re attracted to someone you like how they smell. Like ??? This is just how sex is. Humans are just like that. Faggots understand this
“Ewww sweat is gross” why are you looking for a pristine mountain spring at the bodily fluids store
I feel like people who think armpits are weird are the same people who think anal is kinky. Like. Please free your mind
Submitted by you, voted for by you, I’d like to present the voicelines you were just dying to hear being said by Kim - dutifully performed by the brilliant Jullian Champenois.
Ninjas don’t wear black. They used to disguise themselves as civilians. Unlike ninjas in movies, the real guys were smart enough to know that wearing a black outfit with a face mask wasn’t the best strategy for blending in. Source
But this leaves out the really neat part! The reason we equate the above image with a ninja comes from Kabuki theatre. Within Kabuki theatre there’s a convention of having Kuroko (stage hands) dress in all black (with a full face covering) and move around among the costumed actors in full view, moving scenery, props and costumes. In a similar way, Bunraku puppeteers dress in all black, and only the lead puppeteer’s face would be uncovered. The audience knew to ignore these people and focus on the actors, and to only see that the scene was “magically” changing. So when a play called for a ninja assassin to jump out of nowhere and kill someone, the easiest way to create the surprise reveal was to disguise the ninja in the all black garb of the Kuroko and to remove the face covering and start acting at the last second. This would shock the audience, who were conditioned to not focus on them. Pretty cool, yeah?
WHAT THE FUCK I THOUGHT “STAGE NINJA” WAS JUST A CUTE THEATER TERM FOR CREW. THERE WERE LITERALLY GOD DAMN STAGE NINJAS
AS A FORMER STAGE NINJA I CAN CONFIRM THIS IS BOTH A THING AND AWESOME.
twitter limiting the amount of tweets you get to read per day is ridiculous but if tiktok limited the amount of videos people got to see per day it would be the biggest win for mental health since ssris
